Isolation and Antibiofilm Activity of Bacteriophages against <i>Cutibacterium acnes</i> from Patients with Periprosthetic Joint Infection.

ABSTRACT:

Background

Infections following shoulder surgery, particularly periprosthetic joint infection (PJI), are challenging to treat. Cutibacterium acnes is the causative pathogen in 39% to 76% of these cases. This study explores the efficacy of bacteriophage therapy as an alternative to conventional antibiotics for treating such infections.

Methods

Nine phages with lytic activity were isolated from the skin of humans using C. acnes ATCC 6919 as the indicator host. These phages were tested individually or in combination to assess host range and antibiofilm activity against clinical strains of C. acnes associated with PJIs. The phage cocktail was optimized for broad-spectrum activity and tested in vitro against biofilms formed on titanium discs to mimic the pros

SUBMITTER: Chen B 

PROVIDER: S-EPMC11512206 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature