CT584 Is Not a Protective Vaccine Antigen against Respiratory Chlamydial Challenge in Mice.

ABSTRACT: Background:Chlamydia trachomatis is the most prevalent bacterial sexually transmitted pathogen in humans worldwide. Since chlamydial infection is largely asymptomatic with the potential for serious complications, a preventative vaccine is likely the most viable long-term answer to this public health threat. Cell-free protein synthesis (CFPS) utilizes the cellular protein manufacturing machinery decoupled from the requirement for maintaining cellular viability, offering the potential for flexible, rapid, and decentralized production of recombinant protein vaccine antigens. Methods: Here, we use CFPS to produce the full-length putative chlamydial type three secretion system (T3SS) needle-tip protein, CT584, for evaluation as a vaccine antigen in mouse models. High-speed

SUBMITTER: Hoang-Phou S 

PROVIDER: S-EPMC11512284 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature