Differential Effect of Aldosterone or Mineralocorticoid Receptor Overexpression on Retinal Inflammation.

ABSTRACT:

Purpose

Overactivation of the mineralocorticoid receptor (MR) pathway is proinflammatory and contributes to the pathogenesis of diabetic retinopathy and of age-related macular degeneration. Excess of aldosterone, the specific MR ligand, is known to stimulate the production of proinflammatory cytokines and chemokines in extrarenal tissues and cells. In the RPE/choroid complex, aldosterone upregulated genes encoding proteins of the inflammatory response and downregulated genes encoding proteins involved in synaptic activity and neurotransmitters. Yet, cortisol, which is the main MR ligand in the eye, is a potent anti-inflammatory endogenous glucocorticoid. The aim of the present work was to better understand the role of MR activation in retinal inflammation either by acute injection

SUBMITTER: Leclercq B 

PROVIDER: S-EPMC11512573 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature