Lipidomic Analysis of Microfat and Nanofat Reveals Different Lipid Mediator Compositions.

ABSTRACT:

Background

Microfat and nanofat are commonly used in various surgical procedures, from skin rejuvenation to scar correction, to contribute to tissue regeneration. Microfat contains mainly adipocytes and is well suited for tissue augmentation, and nanofat is rich in lipids, adipose-derived stem cells, microvascular fragments, and growth factors, making it attractive for aesthetic use. The authors have previously demonstrated that the mechanical processing of microfat into nanofat significantly changes its proteomic profile. Considering that mechanical fractionation leads to adipocyte disruption and lipid release, they aimed to analyze their lipidomic profiles for their regenerative properties.

Methods

Microfat and nanofat samples were isolated from 14 healthy patients. Lipido

SUBMITTER: Grunherz L 

PROVIDER: S-EPMC11512614 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature