Antiviral Activity of Nitazoxanide and Miltefosine Against FeHV-1 In Vitro.

ABSTRACT: Feline herpesvirus type 1 (FeHV-1) is a primary pathogen in cats responsible for respiratory and ocular signs. There are presently no antiviral drugs that are officially licensed for veterinary use in several countries. Consequently, veterinarians must depend on off-label antivirals designed for human use. Recent advances in virus-host cell interaction have resulted in new insights into FeHV-1 replication, establishing the importance of the PI3K/Akt axis. The aim of this study was to employ this new information to assess the efficacy of two compounds whose activities involve this pathway. The antiviral properties of miltefosine and nitazoxanide were examined using seven different concentrations, evaluating cell viability and viral titers after 24 h of infection. Furthermore, selected conce

SUBMITTER: Longobardi C 

PROVIDER: S-EPMC11512641 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature