Subcortical origin of nonlinear sound encoding in auditory cortex.

ABSTRACT: A major challenge in neuroscience is to understand how neural representations of sensory information are transformed by the network of ascending and descending connections in each sensory system. By recording from neurons at several levels of the auditory pathway, we show that much of the nonlinear encoding of complex sounds in auditory cortex can be explained by transformations in the midbrain and thalamus. Modeling cortical neurons in terms of their inputs across these subcortical populations enables their responses to be predicted with unprecedented accuracy. By contrast, subcortical responses cannot be predicted from descending cortical inputs, indicating that ascending transformations are irreversible, resulting in increasingly lossy, higher-order representations across the auditory p

SUBMITTER: Lohse M 

PROVIDER: S-EPMC11512679 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature