Sex differences in recovery from postoperative sarcopenia during adjuvant CAPOX therapy for colorectal cancer.

ABSTRACT:

Background

Women are predisposed to develop intolerance to cancer chemotherapy. Sarcopenia and chemotherapy are mutually related. Women are generally intolerable to chemotherapeutics such as 5-fluorouracil. Although adjuvant oxaliplatin-based chemotherapy, e.g. CAPOX is commonly used to treat colorectal cancer, its effects on patients in terms of sarcopenia and sex remain unknown. We investigated sex disparities in the impacts of CAPOX on body composition in this study.

Methods

We conducted a prospective study on diagnostic metrics used for sarcopenia in colorectal cancer patients receiving adjuvant CAPOX. Evaluations of the nutritional status by the Mini-Nutritional Assessment (MNA), gait speed, grip strength, skeletal muscle mass, fat mass, and bone mineral content using a

SUBMITTER: Nozawa H 

PROVIDER: S-EPMC11512877 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature