Urogenital colonization and pathogenicity of E. Coli in the vaginal microbiota during pregnancy.

ABSTRACT: This study explores the role of the vaginal microbiota (VM) in the pathophysiology of asymptomatic bacteriuria (ASB) in a cohort of 1,553 pregnant women. Worldwide, E. coli remains the most common etiological agent of bacteriuria during pregnancy and also a major causative agent of newborn infections. A healthy VM is typically characterized by low diversity and is dominated by lactic acid-producing species, notably those from the Lactobacillus genus. Our results point to decreases in Lactobacillus spp associated with an increase of gut-microbiota-associated species from the Enterobacterales order. Escherichia coli exhibited the most pronounced increase in abundance within the VM during bacteriuria and was notably associated with ASB. Molecular typing and antimicrobial resistance characteri

SUBMITTER: Boutouchent N 

PROVIDER: S-EPMC11513020 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature