Miro2 sulfhydration by CBS/H₂S promotes human trophoblast invasion and migration via regulating mitochondria dynamics.

ABSTRACT: Insufficient cytotrophoblast (CTB) migration and invasion into the maternal myometrium leads to pregnancy related complications like Intra-uterus Growth Restriction (IUGR), and pre-eclampsia (PE). We previously found that hydrogen sulfide (H₂S) enhanced CTB migration without knowing the mechanism(s) and the pathophysiological significance. By studying human samples and cell line, we found that H₂S levels were lower in PE patients' plasma; H₂S synthetic enzyme cystathionine β-synthetase (CBS) was reduced in PE extravillious invasive trophoblasts. GYY4137 (H₂S donor, 1 µM) promoted CBS/H₂S translocation onto mitochondria, preserved mitochondria functions, enhanced cell invasion and migration. CBS knockdown hindered the above functions wh

SUBMITTER: Feng H 

PROVIDER: S-EPMC11513031 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature