A novel methylation-detection panel for HPV associated high-grade squamous intraepithelial lesion and cervical cancer screening.

ABSTRACT: Cervical cancer (CC) was considered to be the most common gynaecological cancer, with an estimated 342,000 deaths worldwide each year, as the majority of patients were diagnosed at an advanced stage of the disease. The purpose of this study was to evaluate the predictive value of multi-locus methylation assay for the early detection of CC. The cervical exfoliated cell samples from 492 HPV-positive females with cervical lesions were collected and subjected to methylation detection of gene FAM19A4, EPB41L3 and PAX1 after bisulfite conversion. The levels of gene methylation in patients with different severity of cervical lesions were evaluated and compared. The receiver-operating characteristic (ROC) curve was established and efficacy indexes such as sensitivity, specificity and area under th

SUBMITTER: Cheng X 

PROVIDER: S-EPMC11513036 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature