DINGO: increasing the power of locus discovery in maternal and fetal genome-wide association studies of perinatal traits.

ABSTRACT: Perinatal traits are influenced by fetal and maternal genomes. We investigate the performance of three strategies to detect loci in maternal and fetal genome-wide association studies (GWASs) of the same quantitative trait: (i) the traditional strategy of analysing maternal and fetal GWASs separately; (ii) a two-degree-of-freedom test which combines information from maternal and fetal GWASs; and (iii) a one-degree-of-freedom test where signals from maternal and fetal GWASs are meta-analysed together conditional on estimated sample overlap. We demonstrate that the optimal strategy depends on the extent of sample overlap, correlation between phenotypes, whether loci exhibit fetal and/or maternal effects, and whether these effects are directionally concordant. We apply our methods to summary s

SUBMITTER: Hwang LD 

PROVIDER: S-EPMC11513127 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature