Organ preservation after neoadjuvant long-course chemoradiotherapy versus short-course radiotherapy.

ABSTRACT:

Background

Potential differences in organ preservation between total neoadjuvant therapy (TNT) regimens integrating long-course chemoradiotherapy (LCCRT) and short-course radiotherapy (SCRT) in rectal cancer remain undefined.

Patients and methods

This natural experiment arose from a policy change in response to the COVID-19 pandemic during which our institution switched from uniformly treating patients with LCCRT to mandating that all patients be treated with SCRT. Our study includes 323 locally advanced rectal adenocarcinoma patients treated with LCCRT-based or SCRT-based TNT from January 2018 to January 2021. Patients who achieved clinical complete response were offered organ preservation with watch-and-wait (WW) management. The primary outcome was 2-year organ preservatio

SUBMITTER: Bercz A 

PROVIDER: S-EPMC11513239 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature