Association of dietary and circulating antioxidant vitamins with metabolic syndrome: an observational and Mendelian randomization study.

ABSTRACT:

Aims

The objective of this study was to investigate the associations of dietary and circulating antioxidant vitamins with metabolic syndrome (MetS), and to assess causality using Mendelian randomization (MR).

Methods

This study included 10,308 participants from the National Health and Nutrition Examination Survey. The associations of vitamins A, C, E and carotenoids with MetS were assessed using multivariable weighted logistic regression analysis. Subsequently, the MR approach was employed to test the causal associations, with inverse variance weighted (IVW) serving as the primary analysis.

Results

Observationally, dietary vitamin A (OR=0.852, 95%CI: 0.727-0.999), C (OR=0.802, 95%CI: 0.675-0.952), carotene (OR=0.832, 95%CI: 0.706-0.982), and β-carotene (OR=0.838, 95%C

SUBMITTER: Sun Q 

PROVIDER: S-EPMC11513263 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature