Subinhibitory concentrations of antibiotics affect development and parameters of Helicobacter pylori biofilm.

ABSTRACT:

Introduction

Helicobacter pylori causes chronic gastric diseases in nearly 50% of people around the world. It is suggested that biofilm formation has a pronounced effect on the dynamic resistance spread and recurrence of these infections.

Methods

To mimic the scenario of therapeutic ineffectiveness, we investigated the impact of sub-minimal inhibitory concentrations (sub-MICs) of antibiotics on the development and parameters of biofilms produced by clinical H. pylori strains.

Results

We observed that constant exposure of planktonic forms to metronidazole or levofloxacin stimulated the speed of autoaggregation and the amount of extracellular matrix, resulting in increased dimensions of the developed biofilms. Contrary to this, continuous exposure to clari

SUBMITTER: Krzyzek P 

PROVIDER: S-EPMC11513322 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature