Induction of neutralizing antibody responses by AAV5-based vaccine for respiratory syncytial virus in mice.

ABSTRACT:

Introduction

Respiratory Syncytial Virus (RSV) is a significant cause of respiratory illnesses worldwide, particularly in infants and elderly individuals. Despite the burden RSV imposes, effective preventive measures are limited. The research application of adeno-associated virus (AAV) in vaccine platforms has been expanding, and its potential in prevention and treatment has garnered much attention.

Methods

In this study, we explored the potential application of a recombinant adeno-associated virus 5 (rAAV5) vector-based RSV vaccine, focusing on the expression of the pre-fusion (Pre-F) protein structure. Through intramuscular immunization in mice. The immunogenicity of the vaccine was evaluated in Balb/c mice immunized intramuscularly and intranasal, respectively.

Results

SUBMITTER: Ma G 

PROVIDER: S-EPMC11513327 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature