Porphyromonas gingivalis triggers microglia activation and neurodegenerative processes through NOX4.

ABSTRACT: Periodontitis and infections with periodontal bacteria have been highlighted as risk factors for dementia. In recent years, attention has been drawn to the role of microglia cells in neurodegenerative diseases. However, there is limited knowledge of the influence of periodontal bacteria on microglia cells. The aim of the present study was to investigate the interactions between the periodontal bacteria Porphyromonas gingivalis and microglia cells and to unravel whether these interactions could contribute to the pathology of Alzheimer's disease. We found, through microarray analysis, that stimulation of microglia cells with P. gingivalis resulted in the upregulation of several Alzheimer's disease-associated genes, including NOX4. We also showed that P. gingivalis lipopo

SUBMITTER: Magnusson A 

PROVIDER: S-EPMC11513391 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature