Inhibition of OXPHOS induces metabolic rewiring and reduces hypoxia in murine tumor models.

ABSTRACT:

Introduction

Tumor hypoxia is a feature of many solid malignancies and is known to cause radio resistance. In recent years it has become clear that hypoxic tumor regions also foster an immunosuppressive phenotype and are involved in immunotherapy resistance. It has been proposed that reducing the tumors' oxygen consumption will result in an increased oxygen concentration in the tissue and improve radio- and immunotherapy efficacy. The aim of this study is to investigate the metabolic rewiring of cancer cells by pharmacological attenuation of oxidative phosphorylation (OXPHOS) and subsequently reduce tumor hypoxia.

Material and methods

The metabolic effects of three OXPHOS inhibitors IACS-010759, atovaquone and metformin were explored by measuring oxygen consumption rate, ext

SUBMITTER: Boreel DF 

PROVIDER: S-EPMC11513494 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature