The adipocyte apolipoprotein M is negatively associated with inflammation.

ABSTRACT: Obesity is associated with the development of local adipose tissue (AT) and systemic inflammation. Most adipokines are upregulated with obesity and have pro-inflammatory properties. Few are downregulated and possess beneficial anti-inflammatory effects. The apolipoprotein M (APOM) is an adipokine whose expression is low during obesity and associated with a metabolically healthy AT. Here, the role of adipose-derived APOM on obesity-associated AT inflammation was investigated by measuring the expression of pro-inflammatory genes in human and mouse models. In 300 individuals with obesity, AT APOM mRNA level was negatively associated with plasma hs-CRP. The inflammatory profile was assessed in Apom^-/- and WT mice fed a normal chow diet (NCD), or a high-fat diet (HFD) to induce AT in

SUBMITTER: Frances L 

PROVIDER: S-EPMC11513530 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature