Tacrolimus Dose Requirement in <i>De Novo</i> Adult Kidney Transplant Patients Treated With Adoport^® Can Be Anticipated.

ABSTRACT: All the factors potentially influencing tacrolimus dose requirement and combinations thereof have never been thoroughly investigated, precluding accurate prediction of tacrolimus starting dose. This prospective, non-interventional, multicenter study in de novo adult kidney transplant recipients over the first year after transplantation aimed to investigate the factors influencing tacrolimus dose-standardized trough blood concentration (C₀/D) over the first week post-transplant (D4-D7, primary objective), D8-M3 and M3-M12 (secondary objectives). Statistical analysis employed mixed linear models with repeated measures. Eighteen sites enrolled 440 patients and followed them up for 9.5 ± 4.1 months. Age at baseline (p = 0.0144), end-stage renal disease (p = 0.00

SUBMITTER: Marquet P 

PROVIDER: S-EPMC11513580 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature