Sex differences in behavior, cognitive, and physiological recovery following methamphetamine administration.

ABSTRACT: Intact executive functions are required for proper performance of cognitive tasks and relies on balance of excitatory and inhibitory (E/I) transmission in the medial prefrontal cortex (mPFC). Hypofrontality is a state of decreased activity in the mPFC and is seen in several neuropsychiatric conditions, including substance use disorders. People who chronically use methamphetamine (meth) develop hypofrontality and concurrent changes in cognitive processing across several domains. Despite the fact that there are sex difference in substance use disorders, few studies have considered sex as a biological variable regarding meth-mediated hypoactivity in mPFC and concurrent cognitive deficits. Hypofrontality along with changes in cognition are emulated in rodent models following repeated meth admi

SUBMITTER: Armenta-Resendiz M 

PROVIDER: S-EPMC11513735 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature