Breast cancer and neoplasms of the thyroid gland: a bidirectional two-sample Mendelian randomization study.

ABSTRACT:

Background

With the rising incidence of breast cancer (BC) and neoplasms of the thyroid gland, a potential link between the two has drawn increasing attention. However, the causal relationship remains unclear due to various confounding factors. This study aims to investigate the causality between BC and thyroid tumors using Mendelian Randomization (MR) analysis.

Methods

We conducted a bidirectional two-sample MR analysis, utilizing breast cancer-associated single nucleotide polymorphisms (SNPs) from the Breast Cancer Association Consortium (BCAC) and thyroid tumor-related SNPs from the FinnGen (https://www.finngen.fi/) database. First, we performed univariable MR (UVMR) to assess the causal relationship between BC and both malignant and benign thyroid tumors, followed by rev

SUBMITTER: Sun Y 

PROVIDER: S-EPMC11513776 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature