Inflammatory Cytokines and Cognition in Alzheimer's Disease and Its Prodrome.

ABSTRACT:

Objective

The aim of this study was to investigate the association between blood levels of tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) and cognitive impairments among elderly individuals.

Methods

Peripheral concentration of TNF-α and IL-6 were measured in all subjects. To assess individual cognitive function, the Consortium to Establish a Registry for Alzheimer's Disease Neuropsychological Assessment Battery (CERAD-NP) was used, and standardized scores (z-scores) were calculated for each test. Cytokine levels were compared between the diagnostic groups, and correlations between blood inflammatory factor levels and z-scores were analyzed.

Results

The 37 participants included 8 patients with Alzheimer's disease (AD), 15 subjects with mild cognitive impairme

SUBMITTER: Seong SJ 

PROVIDER: S-EPMC11513865 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature