Gene therapy for <i>fat-1</i> prevents obesity-induced metabolic dysfunction, cellular senescence, and osteoarthritis.

ABSTRACT: Obesity is one of the primary risk factors for osteoarthritis (OA), acting through cross talk among altered biomechanics, metabolism, adipokines, and dietary free fatty acid (FA) composition. Obesity and aging have been linked to cellular senescence in various tissues, resulting in increased local and systemic inflammation and immune dysfunction. We hypothesized that obesity and joint injury lead to cellular senescence that is typically associated with increased OA severity or with aging and that the ratio of omega-6 (ω-6) to omega-3 (ω-3) FAs regulates these pathologic effects. Mice were placed on an ω-6-rich high-fat diet or a lean control diet and underwent destabilization of the medial meniscus to induce OA. Obesity and joint injury significantly increased cellular senescence in subcut

SUBMITTER: Tang R 

PROVIDER: S-EPMC11513907 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature