Free radical detection in precision-cut mouse liver slices with diamond-based quantum sensing.

ABSTRACT: Free radical generation plays a key role in many biological processes including cell communication, maturation, and aging. In addition, free radical generation is usually elevated in cells under stress as is the case for many different pathological conditions. In liver tissue, cells produce radicals when exposed to toxic substances but also, for instance, in cancer, alcoholic liver disease and liver cirrhosis. However, free radicals are small, short-lived, and occur in low abundance making them challenging to detect and especially to time resolve, leading to a lack of nanoscale information. Recently, our group has demonstrated that diamond-based quantum sensing offers a solution to measure free radical generation in single living cells. The method is based on defects in diamonds, the so-ca

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC11513939 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature