Antioxidant and anticoagulant properties of myo-inositol determined in an ex vivo studies and gas chromatography analysis.

ABSTRACT: Myo-inositol plays a key role in the vasculature and may be beneficial for preventing harmful environmental effects. In this study aortic rings were isolated from middle-aged (12-month-old) male Wistar rats and preincubated with myo-inositol (0.01-100 mg/L) for 2 h. A stable thromboxane A₂ analog was added (0.1 nM, 2 h) to analyze vascular dysfunction. The concentration of myo-inositol in the organ baths was determined via gas chromatography. In another experiment, human blood plasma was subjected to pro-oxidant - hydrogen peroxide administration, and myo-inositol was added to analyze lipid and protein oxidation processes. The thromboplastin time, prothrombin time, and thrombin time were also studied. Myo-inositol administration protected thiol groups against oxidative stress, m

SUBMITTER: Rolnik A 

PROVIDER: S-EPMC11514185 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature