Association of FTO variants rs9939609 and rs1421085 with elevated sugar and fat consumption in adult obesity.

ABSTRACT: This cross-sectional study explores the impact of FTO gene single nucleotide polymorphisms (SNPs) rs9939609 and rs1421085 on dietary habits contributing to obesity risk in Thai adults. The study enrolled 384 participants from Bangkok, categorized as non-obese (BMI < 25 kg/m²) or obese (BMI ≥ 25 kg/m²) based on WHO Asia Pacific Guidelines. Genotyping for FTO variants was performed using DNA from blood samples. While both SNPs adhered to Hardy-Weinberg equilibrium, the association between risk alleles and anthropometric measurements was not statistically significant. However, risk allele carriers showed significantly higher intakes of sugar and saturated fat compared to homozygous dominant individuals. In the obese group, the odds ratio for high-sugar intake was 2.22 (9

SUBMITTER: Poosri S 

PROVIDER: S-EPMC11514288 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature