Leveraging the Aggregated Protein Dye YAT2150 for Malaria Chemotherapy.

ABSTRACT: Background/Objectives: YAT2150 is a first-in-class antiplasmodial compound that has been recently proposed as a new interesting drug for malaria therapy. Methods/Results: The fluorescence of YAT2150 rapidly increases upon its entry into Plasmodium, a property that can be of use for the design of highly sensitive diagnostic approaches. YAT2150 blocks the in vitro development of the ookinete stage of Plasmodium and, when added to an infected blood meal, inhibits oocyst formation in the mosquito. Thus, the compound could possibly contribute to future transmission-blocking antimalarial strategies. Cell influx/efflux studies in Caco-2 cells suggest that YAT2150 is internalized by endocytosis and also through the OATP2B1 transporter, whereas its main export route woul

SUBMITTER: Camarero-Hoyos C 

PROVIDER: S-EPMC11514582 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature