The intra-tumoral microbiome as a potential biomarker of response to external beam radiation therapy in cervical cancer.

ABSTRACT:

Background

We aimed to determine the potential predictive value of the intra-tumoral microbiome as a marker of the response to external beam radiation therapy (EBRT) in cervical cancer (CC).

Methods

A prospective longitudinal trial of 36 CC patients receiving pelvic radiotherapy was designed to investigate microbial characteristic signatures and diversity (alpha and beta) of multiple sites (tumor, vaginal, gut, urethral, and oral) in the superior response (SR) and inferior response (IR) groups of CC patients by 16S rRNA sequencing. Utilized the least absolute shrinkage and selection operator (LASSO) logistic regression method to analyze clinicopathological factors that potentially influenced the efficacy of EBRT. LEfSe analysis highlighted the microbiome features that best d

SUBMITTER: Dou Z 

PROVIDER: S-EPMC11514760 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature