Effect of diabetes mellitus type 2 and sulfonylurea on colorectal cancer development: a case-control study.

ABSTRACT:

Background and aims

Colorectal cancer (CRC) is a significant global health concern, with studies estimating a rise in new cases to 2.5 million by 2035. Type 2 diabetes (T2D) is also a growing issue, with an estimated 642 million adults affected by 2040. However, the relationship between T2D, its medications, and CRC remains unclear.

Materials and methods

This case-control study includes 810 controls without CRC and 684 cases with CRC admitted to Rasoul-Akram and Firouzgar Hospitals from September 2019 to 2023. Adjusted and unadjusted odds ratios (OR) were calculated to investigate the effect of T2D and sulfonylurea consumption on the chance of CRC development, using univariate and multivariate logistic regression analyses. The relationship between T2D and the clinicopatholog

SUBMITTER: Rezazadeh M 

PROVIDER: S-EPMC11514850 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature