Improving criteria for dissemination in space in multiple sclerosis by including additional regions.

ABSTRACT:

Objective

We investigated the effects of adding regions to current dissemination in space (DIS) criteria for multiple sclerosis (MS).

Methods

Participants underwent brain, optic nerve, and spinal cord MRI. Baseline DIS was assessed by 2017 McDonald criteria and versions including optic nerve, temporal lobe, or corpus callosum as a fifth region (requiring 2/5), a version with all regions (requiring 3/7) and optic nerve variations requiring 3/5 and 4/5 regions. Performance was evaluated against MS diagnosis (2017 McDonald criteria) during follow-up.

Results

Eighty-four participants were recruited (53F, 32.8 ± 7.1 years). 2017 McDonald DIS criteria were 87% sensitive (95% CI: 76-94), 73% specific (50-89), and 83% accurate (74-91) in identifying MS. Modified criteria with

SUBMITTER: Foster MA 

PROVIDER: S-EPMC11514922 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature