Dataset Information

Transactivation of the EGF receptor as a novel desensitization mechanism for G protein-coupled receptors, illustrated by dopamine D2-like and β₂ adrenergic receptors.

ABSTRACT: Transactivation of epidermal growth factor receptors (EGFR) provides intricate control over multiple regulatory cellular processes that merge the diversity of G protein-coupled receptors (GPCRs) with the robust signaling capacities of receptor tyrosine kinases. Contrary to the typical assertions, our findings demonstrate that EGFR transactivation contributes to the desensitization of GPCRs. Repeated agonist stimulation of certain GPCRs enhanced EGFR transactivation, triggering a series of cellular events associated with GPCR desensitization. This effect was observed in receptors undergoing desensitization (D₃R, K149C-D₂R, β₂AR) but not in those resistant to desensitization (D₂R, C147K-D₃R, D₄R, β₂AR mutants lackin

SUBMITTER: Kundu D

PROVIDER: S-EPMC11514929 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature

ACCESS DATA

Dataset Information

Transactivation of the EGF receptor as a novel desensitization mechanism for G protein-coupled receptors, illustrated by dopamine D2-like and β₂ adrenergic receptors.

OmicsDI is part of the ELIXIR infrastructure

Tweets

Dataset Information

Transactivation of the EGF receptor as a novel desensitization mechanism for G protein-coupled receptors, illustrated by dopamine D2-like and β2 adrenergic receptors.

OmicsDI is part of the ELIXIR infrastructure

Tweets

Transactivation of the EGF receptor as a novel desensitization mechanism for G protein-coupled receptors, illustrated by dopamine D2-like and β₂ adrenergic receptors.