Impact of selective reporting bias on stroke trials: potential compromise in evidence synthesis - A cross-sectional study.

ABSTRACT:

Background

Accurate reporting of outcomes is crucial for interpreting the results of randomized controlled trials (RCTs). However, selectively reporting outcomes in publications to achieve researchers' anticipated results still occurs frequently. This study aims to investigate the prevalence of selective reporting of outcomes in RCTs on treating acute ischemic stroke (AIS), identify factors contributing to this issue, and assess its potential impact on the degree and direction of intervention effect.

Methods

A search was conducted in MEDLINE, Embase, and the Cochrane Library to collect interventional RCTs on AIS published from 2020 to 2022. Full texts of RCTs were reviewed, and only those reporting International Clinical Trials Registry Platform primary registry numbers were

SUBMITTER: Wang X 

PROVIDER: S-EPMC11514957 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature