Preferences for genetic interventions for SCA and Huntington's disease: results of a discrete choice experiment among patients.

ABSTRACT:

Background

Although genetic interventions are on the horizon for some polyglutamine expansion diseases, such as subtypes of spinocerebellar ataxia (SCA) and Huntington's disease (HD), the patients' preferences regarding these new therapies are unclear. This study aims to get insight into what extent different characteristics of genetic interventions affect the preferences of patients with SCA and HD with regard to these interventions.

Methods

Manifest and premanifest patients with SCA or HD were recruited online by platforms of patient associations. The respondents conducted a questionnaire that included a discrete choice experiment (DCE). The experimental design included 24 choice sets, but these were divided into three blocks of eight to reduce the number of tasks per resp

SUBMITTER: van Os NJH 

PROVIDER: S-EPMC11514962 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature