Metabolomic analysis to predict the onset and severity of necrotizing enterocolitis.

ABSTRACT:

Background

Necrotizing enterocolitis (NEC) is the most devastating gastrointestinal (GI) emergency in preterm neonates. Untargeted metabolomics may allow the identification of biomarkers involved in NEC pathophysiology.

Methods

We conducted a prospective study including preterm infants born at < 34 gestational weeks (GWs) whose urine was longitudinally collected at birth (< 48 h, T0) and at 14 (T1) and 28 days (T2). Neonates were followed for their development of NEC, spontaneous intestinal perforation (SIP), or other GI conditions and compared to those of matched healthy controls. Urine samples were investigated by untargeted metabolomic analysis based on mass-spectrometry.

Results

Thirty-five patients with NEC, 5 patients with SIP, 14 patients with other GI diseases

SUBMITTER: Moschino L 

PROVIDER: S-EPMC11515140 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature