Identification and validation of key extracellular proteins as the potential biomarkers in diabetic nephropathy.

ABSTRACT:

Objective

Accumulation of extracellular matrix (ECM) proteins in the glomerular mesangial region is a typical hallmark of diabetic nephropathy (DN). However, the molecular mechanism underlying ECM accumulation in the mesangium of DN patients remains unclear. The present study aims to establish a connection between extracellular proteins and DN with the goal of identifying potential biomarkers for this condition.

Methods

Differentially expressed genes (DEGs) between DN kidney tissue and healthy kidney tissue were analyzed using the public data GSE166239. Two gene lists encoding extracellular proteins were then utilized to identify extracellular protein-differentially expressed genes (EP-DEGs). Functional enrichment analyses, including Gene Ontology (GO) and Kyoto Encyclopedia

SUBMITTER: Pan W 

PROVIDER: S-EPMC11515200 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature