Identification of molecular subtypes based on bile acid metabolism in cholangiocarcinoma.

ABSTRACT:

Background

Cholangiocarcinoma is a highly heterogeneous tumor with bile acid metabolism involving in its development. The aim of this study was to characterize bile acid metabolism and identify specific subtypes to better stratify cholangiocarcinoma patients for individualized treatment and prognostic assessment.

Methods

A total of 30 bile acids were quantified using the ultra-performance liquid chromatography tandem mass spectrometry. Using Consensus clustering, the molecular subtypes related to bile acid metabolism were identified. The prognosis, clinicopathologic characteristics, immune landscape, and therapeutic response were compared between these subtypes. The single-cell RNA sequencing (scRNA-seq) analysis and preliminary cell experiment were also conducted to verify

SUBMITTER: Deng M 

PROVIDER: S-EPMC11515294 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature