Identification of novel sub-phenotypes of severe ARDS requiring ECMO using latent class analysis.

ABSTRACT:

Background

Sub-phenotyping of acute respiratory distress syndrome (ARDS) could be useful for evaluating the severity of ARDS or predicting its responsiveness to given therapeutic strategies, but no studies have yet investigated the heterogeneity of patients with severe ARDS requiring veno-venous extracorporeal membrane oxygenation (V-V ECMO).

Methods

We conducted this retrospective multicenter observational study in adult patients with severe ARDS treated by V-V ECMO. We performed latent class analysis (LCA) for identifying sub-phenotypes of severe ARDS based on the radiological and clinical findings at the start of ECMO support. Multivariate Cox regression analysis was conducted to investigate the differences in mortality and association between the PEEP setting of ≥ 10 cmH

SUBMITTER: Nishikimi M 

PROVIDER: S-EPMC11515347 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature