Gut-first Parkinson's disease is encoded by gut dysbiome.

ABSTRACT:

Background

In Parkinson's patients, intestinal dysbiosis can occur years before clinical diagnosis, implicating the gut and its microbiota in the disease. Recent evidence suggests the gut microbiota may trigger body-first Parkinson Disease (PD), yet the underlying mechanisms remain unclear. This study aims to elucidate how a dysbiotic microbiome through intestinal immune alterations triggers PD-related neurodegeneration.

Methods

To determine the impact of gut dysbiosis on the development and progression of PD pathology, wild-type male C57BL/6 mice were transplanted with fecal material from PD patients and age-matched healthy donors to challenge the gut-immune-brain axis.

Results

This study demonstrates that patient-derived intestinal microbiota caused midbrain tyrosin

SUBMITTER: Munoz-Pinto MF 

PROVIDER: S-EPMC11515425 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature