High expression of PLA2G2A in fibroblasts plays a crucial role in the early progression of carotid atherosclerosis.

ABSTRACT:

Background

In mouse models of atherosclerosis, knockout of the PLA2G2A gene has been shown to reduce the volume of atherosclerotic plaques. Clinical trials have demonstrated the potential of using the sPLA2 inhibitor Varespladib in combination with statins to reduce lipid levels. However, this approach has not yielded the expected results in reducing the risk of cardiovascular events. Therefore, it is necessary to further investigate the mechanisms of PLA2G2A.

Methods

Single-cell transcriptome data from two sets of carotid plaques, combined with clinical patient information. were used to describe the expression characteristics of PLA2G2A in carotid plaques at different stages. In order to explore the mechanisms of PLA2G2A, we conducted enrichment analysis, cell-cell communic

SUBMITTER: Wang X 

PROVIDER: S-EPMC11515432 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature