Pathogenic nsSNPs of protein kinase C-eta with hepatocellular carcinoma susceptibility.

ABSTRACT:

Background

Hepatocellular carcinoma (HCC) is a global health concern. Due to late diagnosis and limited therapeutic strategies, HCC based mortality rate is exponentially increasing globally. Genetic predisposition is a non-avoidable intrinsic factor that could alter the genome sequence, ultimately leading to HCC. Protein kinase C eta (PKCη) is involved in key physiological roles, hence alteration in PKCη could aid in cancer progression. Research indicates association between non-synonymous (ns) SNPs and HCC onset. However, effect of nsSNP variants of PKCη on HCC development has not been explored yet. Hence, this study aimed to investigate the association between pathogenic nsSNPs of PKCη with HCC.

Methods

Non-synonymous (missense) variants of PKCη were obtained from Ensembl

SUBMITTER: Hussain T 

PROVIDER: S-EPMC11515447 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature