Epigenome-wide analysis across the development span of pediatric acute lymphoblastic leukemia: backtracking to birth.

ABSTRACT:

Background

Cancer is the leading cause of disease-related mortality in children. Causes of leukemia, the most common form, are largely unknown. Growing evidence points to an origin in-utero, when global redistribution of DNA methylation occurs driving tissue differentiation.

Methods

Epigenome-wide DNA methylation was profiled in surrogate (blood) and target (bone marrow) tissues at birth, diagnosis, remission and relapse of pediatric pre-B acute lymphoblastic leukemia (pre-B ALL) patients. Double-blinded analyses was performed between prospective cohorts extending from birth to diagnosis and retrospective studies backtracking from clinical disease to birth. Validation was carried out using independent technologies and populations.

Results

The imprinted and immuno-modu

SUBMITTER: Ghantous A 

PROVIDER: S-EPMC11515509 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature