Unraveling the glycosphingolipid metabolism by leveraging transcriptome-weighted network analysis on neuroblastic tumors.

ABSTRACT:

Background

Glycosphingolipids (GSLs) are membrane lipids composed of a ceramide backbone linked to a glycan moiety. Ganglioside biosynthesis is a part of the GSL metabolism, which involves sequential reactions catalyzed by specific enzymes that in part have a poor substrate specificity. GSLs are deregulated in cancer, thus playing a role as potential biomarkers for personalized therapy or subtype classification. However, the analysis of GSL profiles is complex and requires dedicated technologies, that are currently not included in the commonly utilized high-throughput assays adopted in contexts such as molecular tumor boards.

Methods

In this study, we developed a method to discriminate the enzyme activity among the four series of the ganglioside metabolism pathway by incorpo

SUBMITTER: Ustjanzew A 

PROVIDER: S-EPMC11515559 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature