Genetic polymorphism involved in major depressive disorder: a systemic review and meta-analysis.

ABSTRACT:

Background and objective

Genetic polymorphism studies in families and twins indicated the heritability of depression. However, the association between genes with genetic polymorphism and depression provides various findings and remains unclear. Therefore, we conducted a systematic review and meta-analysis to determine the genes with their polymorphism associated with the symptomatic depression known as major depressive disorder (MDD).

Materials and methods

PubMed and Scopus were searched for relevant studies published before May 22, 2023 (1968-2023), and 62 were selected for this review. The study's bias risk was investigated using the Newcastle-Ottawa scale. Gene functional enrichment analysis was investigated for molecular function (MF) and biological process (BP) and path

SUBMITTER: Suktas A 

PROVIDER: S-EPMC11515766 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature