Effect of genistein supplementation on microenvironment regulation of breast tumors in obese mice.

ABSTRACT: Obesity is an important risk factor for breast cancer in women before and after menopause. Adipocytes, key mediators in the tumor microenvironment, play a pivotal role in the relationship between obesity with cancer. However, the potential of dietary components in modulating this relationship remains underexplored. Genistein, a soy-derived isoflavone, has shown promise in reducing breast cancer risk, attenuating obesity-associated inflammation, and improving insulin resistance. However, there are no reports examining whether genistein has the ability to reduce the effects of obesity on breast tumor development. In this study, we constructed a mammary tumor model in ovariectomized obese mice and examined the effects of genistein on body condition and tumor growth. Moreover, the effects of g

SUBMITTER: Jin S 

PROVIDER: S-EPMC11515845 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature