Joint estimation of compartment-specific T₂ relaxation and tumor microstructure using multi-TE IMPULSED MRI.

ABSTRACT:

Purpose

This study aims to assess how T2 heterogeneity biases IMPULSED-derived metrics of tissue microstructure in solid tumors and evaluate the potential of estimating multi-compartmental T2 and microstructural parameters simultaneously.

Methods

This study quantifies the impact of T2 relaxation on IMPULSED-derived microstructural parameters using computer simulations and in vivo multi-TE IMPULSED MRI in five tumor models, including brain, breast, prostate, melanoma, and colon cancer. A comprehensive T₂ + IMPULSED method was developed to fit multi-compartmental T₂ and microstructural parameters simultaneously. A Bayesian model selection approach was carried out voxel-wisely to determine if the T₂ heterogeneity needs to be included in IMPULSED

SUBMITTER: Jiang X 

PROVIDER: S-EPMC11518654 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature