Investigating the causal relationship between human blood metabolites and pulmonary hypertension: a two-sample Mendelian randomization study.

ABSTRACT:

Background

Several recent investigations have posited that distinct metabolites in the bloodstream may be correlated with the pathogenesis of Pulmonary Hypertension (PH). Nonetheless, the interrelationship between the pathogenesis of PH and metabolite fluctuations remains incompletely elucidated, and findings may differ across studies.

Methods

In the extant research, data from 486 metabolite-and PH-related genetic variants in human subjects were procured based on Genome-Wide Association Studies (GWAS) and Finnish databases. Univariate Mendelian Randomization analyses were deployed to evaluate the causal relationships between them. The utilization of the randomized Inverse Variance weighted(IVW) method served as the primary analytic framework in this Mendelian Randomization (

SUBMITTER: Zeng X 

PROVIDER: S-EPMC11518716 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature