Pharmacological targeting of smoothened receptor cysteine-rich domain by Budesonide promotes in vitro myelination.

ABSTRACT:

Background

The myelin sheath ensures efficient nerve impulse transmission along the axons. Remyelination is a spontaneous process that restores axonal insulation, promoting neuroprotection and recovery after myelin damage. There is an urgent need for new pharmacological approaches to remyelination and to improve the most effective molecules. Some glucocorticoids (GC) were identified through phenotypical screens for their promyelinating properties. These GC compounds share the ability to bind the Smoothened (Smo) receptor of the Hedgehog (Hh) pathway. Gaining a deeper insight into how they modulate Smo receptor activity could guide structure-based studies to leverage the GCs' potent promyelinating activity for a more targeted approach to remyelination.

Methods

Here we focused

SUBMITTER: Recchia AD 

PROVIDER: S-EPMC11518828 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature