Clinical parameters affect the structure and function of superficial pyramidal neurons in the adult human neocortex.

ABSTRACT: The interplay between neuronal structure and function underpins the dynamic nature of neocortical networks. Despite extensive studies in animal models, our understanding of structure-function interrelations in the adult human brain remains incomplete. Recent methodological advances have facilitated the functional analysis of individual neurons within the human neocortex, providing a new understanding of fundamental brain processes. However, the factors contributing to patient-specific neuronal properties have not been thoroughly explored. In this observational study, we investigated the structural and functional variability of superficial pyramidal neurons in the adult human neocortex. Using whole-cell patch-clamp recordings and post hoc analyses of dendritic spine morphology in acu

SUBMITTER: Lenz M 

PROVIDER: S-EPMC11518857 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature