Lactate and hydrogen ions play a predominant role in evoking the exercise pressor reflex during ischaemic contractions but not during freely perfused contractions.

ABSTRACT: We investigated the role played by lactate and hydrogen in evoking the exercise pressor reflex (EPR) in decerebrated rats whose hindlimb muscles were either freely perfused or ischaemic. Production of lactate and hydrogen by the contracting hindlimb muscles was manipulated by knocking out the myophosphorylase gene (pygm). In knockout rats (pygm^-/-; n = 13) or wild-type rats (pygm^+/+; n = 13), the EPR was evoked by isometrically contracting the triceps surae muscles. Blood pressure, tension, blood flow, renal sympathetic nerve activity and blood lactate concentrations were measured. Intramuscular metabolites and pH changes induced by the contractions were quantified by ³¹P-magnetic resonance spectroscopy (n = 5). In a subset of pygm^-/- rats (n = 5

SUBMITTER: Ducrocq GP 

PROVIDER: S-EPMC11518877 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature