Neuron-specific deficiency of autophagy increases neuronal loss in traumatic brain injury.

ABSTRACT: The involvement of neuronal autophagy in traumatic brain injury (TBI) remains elusive. Previous investigations, as far as our knowledge extends, have modulated autophagy either through systemic administration of autophagy inhibitors/inducers or by eliminating key regulators of autophagy across all somatic cells, lacking specificity for neurons. Consequently, drawing conclusions from such studies may be muddled by inhibiting autophagy in other cell types, including astrocytes, microglia, and immune cells. To discern the precise role of neuronal autophagy in TBI, we generated tamoxifen-induced, neuron-specific, autophagy-deficient mice by crossing atg5 ^flox/flox mice with map2-CreER^T2 mice. We then induced TBI in either control mice or mice with neuron-spe

SUBMITTER: Pei C 

PROVIDER: S-EPMC11518936 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature